GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs10205487 | 1 | rs11126251 | chr2:70163434 | ANXA4 | chr2:69969127-70053594:+ | -0.15 | -4.45 | 9.48E-6 | Carotid plaque burden (smoking interaction) |
| BRCA | cis | rs6547741 | 1 | rs11127071 | chr2:27838058 | KRTCAP3 | chr2:27665263-27667163:+ | -0.13 | -4.1 | 4.45E-5 | Oral cavity cancer |
| BRCA | cis | rs4372836 | 1 | rs11127188 | chr2:28972852 | TRMT61B | chr2:29072690-29093175:- | -0.25 | -6.26 | 5.49E-10 | Body mass index |
| BRCA | cis | rs2241437 | 1 | rs111295372 | chr2:86283357 | LOC90784 | chr2:86247339-86250991:- | -0.45 | -5.46 | 6.05E-8 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| BRCA | cis | rs9876781 | 1 | rs11130170 | chr3:48449897 | TREX1 | chr3:48501186-48509043:+ | -0.29 | -10.92 | 2.27E-26 | Longevity |
| BRCA | cis | rs9876781 | 1 | rs11130171 | chr3:48462461 | TREX1 | chr3:48501186-48509043:+ | -0.27 | -10.1 | 5.59E-23 | Longevity |
| BRCA | cis | rs7647973 | 1 | rs11130190 | chr3:49402137 | AMT | chr3:49454212-49460012:- | 0.14 | 4.69 | 3.12E-6 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11130190 | chr3:49402137 | CCDC36 | chr3:49235861-49295537:+ | 0.1 | 3.93 | 8.91E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11130190 | chr3:49402137 | NCKIPSD | chr3:48711280-48723334:- | 0.15 | 3.89 | 0.000105 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11130190 | chr3:49402137 | P4HTM | chr3:49027341-49044579:+ | 0.1 | 4.29 | 1.96E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11130190 | chr3:49402137 | WDR6 | chr3:49044637-49053386:+ | -0.13 | -3.89 | 0.000109 | Menarche (age at onset) |
| BRCA | cis | rs9858542 | 1 | rs11130213 | chr3:49712297 | AMT | chr3:49454212-49460012:- | 0.11 | 3.67 | 0.000256 | Crohn's disease;Ulcerative colitis |
| BRCA | cis | rs3749237 | 1 | rs11130214 | chr3:49735746 | CCDC36 | chr3:49235861-49295537:+ | -0.08 | -3.39 | 0.000712 | Resting heart rate |
| BRCA | cis | rs3749237 | 1 | rs11130214 | chr3:49735746 | DALRD3 | chr3:49052435-49058467:- | -0.12 | -4.19 | 3.07E-5 | Resting heart rate |
| BRCA | cis | rs3749237 | 1 | rs11130214 | chr3:49735746 | P4HTM | chr3:49027341-49044579:+ | -0.09 | -3.98 | 7.4E-5 | Resting heart rate |